Since its establishment in 1972, ISSP has provided a basic science support to the emerging Bulgarian microelectronics and solar energy utilization. Two independent institutes were nucleated from ISSP, the Institute of Microelectronics and the Central Laboratory of Solar Energy and New Energy Sources. We played a leading role in condensed matter physics, laser physics, theory of solid state, theory of phase transitions, superconductivity and superconducting materials, low temperature physics, liquid crystal physics, physics of living matter, structure and properties of crystals and amorphous materials, atom and plasma physics, acoustoelectronics and microelectronics. We provided valuable research results in energy, the environment, national defense, materials, healthcare, integral and functional microelectronics. We shared these results with universities and industry nationwide. We have also been successful in training new talents on both national and international level. Today, as members of the European Research Area, we are looking for a new future in the country’s transition to knowledge-based economy and in the globalization and convergence of technologies. Our commitment remains to continuing innovation and upholding the vision of the scientists who have established ISSP more than 40 years ago. We are determined to stay a leading national institute in the condensed matter theory, physics of new materials, nanophysics, micro- and acoustoelectronics, low temperature physics, physical optics and optical methods, soft and living matter physics, laser, atomic, molecular and plasma physics. We also wish to find our proper and deserved place in the scientific establishment of United Europe and the world. To this aim, we are actively involved in the global academic research and industrial collaboration. ISSP with its longstanding reputation and depth of experience is a valuable asset for Bulgaria, and can be a driving force for its economic growth. First steps as the formation of a business incubator for SME business have already been done by us. It is a long way ahead that will lead us to new break-troughs in science and technology for the benefit of our knowledge-based society.